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It also promotes synthesis of elastin, glycosaminoglycans, and other matrix components that give tissues their characteristic properties

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Figures 1B , 3 ), resulting in down-regulation of the hepatic GHR expression, as inferred from reductions in circulating levels of GHBP ( In the setting of chronic inflammatory disease states (e.g., Crohn’s disease or juvenile chronic arthritis), these diseases can also disturb the physiological synergy of the GH/IGF-I axis